Hi, Thanks for posting in HCM. I understand your concern. Nicotine is a potent parasympathomimetic alkaloid, which is used as a stimulant drug. Nicotine on entering the body is distributed quickly through the bloodstream and crosses the blood–brain barrier reaching the brain within 10 – 20 seconds after inhalation. Nicotine is metabolized in the liver by cytochrome P450 enzymes. Elimination half-life of nicotine in the body is around two hours. Hope the information provided would be helpful. All the best.