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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Hepatitis C Positive. Treatment Started With Pegintron, Ribavirin. Virus Still Present In Blood. Worried About Health?

Hi. My father is of 49 year age. He has hepatitus c positive since year 2004 with genotype 3. In 2005, he was treated with Pegasys with ribavirin for 6 months but unfortunately the treatment was not successfull. Again after break of 7 years his treatment was started 6 months before with Pegintron with Ribavirin. Doctor suggested that the treatment will last for a year. After 6 months, the virus is still present in the blood with the Real time PCR quantitative1600 IU/ml. At the start of treatment it was 922,812 IU/ml. My family is too much worried about him. Kindly guide....?Are results satisfactory?
Sat, 23 Mar 2013
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General & Family Physician 's  Response
Hi,

Based on the treatment information every things look pretty good.

(1) Let me give you some information about clinical trial for genotype-3 treatment, it shows that 24 week treatment only cures 65% of patients so in order to achieve or cover the complete 100% case it need to have 40 weeks treatment, so in theory we will be able to cure 100% cases. But we are taking year worth of medicine will cure you from HEP-C WITH 130% result, hope it makes sense, if not try to read it again, More over in simple words you will be cured completely even before 12 months of medication but YOU ARE a reoccurrence case so taking medication for 12 months is a great option.

(2) Now let talk about the PCR- IT REDUCED BY MANY FOLDS from 922,812 IU/ml to 1600 IU/ml. Its the best result one can have.
So from that estimate the PCR Will be near zero in next 3 months but please continue taking medication as physician has asked for, as this is a naught disease and can reoccur if not cured completely .

(3) PLEASE let your family know that things are working fine even better then expected, so their is nothing to worry about and will be as normal as before after 6 months of treatment.

Hope its helps.



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Hepatitis C Positive. Treatment Started With Pegintron, Ribavirin. Virus Still Present In Blood. Worried About Health?

Hi, Based on the treatment information every things look pretty good. (1) Let me give you some information about clinical trial for genotype-3 treatment, it shows that 24 week treatment only cures 65% of patients so in order to achieve or cover the complete 100% case it need to have 40 weeks treatment, so in theory we will be able to cure 100% cases. But we are taking year worth of medicine will cure you from HEP-C WITH 130% result, hope it makes sense, if not try to read it again, More over in simple words you will be cured completely even before 12 months of medication but YOU ARE a reoccurrence case so taking medication for 12 months is a great option. (2) Now let talk about the PCR- IT REDUCED BY MANY FOLDS from 922,812 IU/ml to 1600 IU/ml. Its the best result one can have. So from that estimate the PCR Will be near zero in next 3 months but please continue taking medication as physician has asked for, as this is a naught disease and can reoccur if not cured completely . (3) PLEASE let your family know that things are working fine even better then expected, so their is nothing to worry about and will be as normal as before after 6 months of treatment. Hope its helps.