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Had bypass. Given zyvox with other medicines. Experiencing hallucinations. Side effects of drug?

Hi, I am wondering if there are any long lasting side effects from a drug interaction with the drug zyvox. My husband had 4 bypass and he was given zyvox and he also takes buspirone , bupropion and fluoxetine and venlafaxine . He had hallucinations, ect after being given that and we are concerned what the side effects can be.
Asked On : Thu, 28 Feb 2013
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Internal Medicine Specialist 's  Response
Thanks for coming to HCM. Sorry to hear about your problems.

I am assuming here that your husband was not taking any other medicines than what you indicated in your query. Zyvox is a good antibiotic but has risk of interactions with several drugs.

Using Zyvox (linezolid) with venlafaxine and/or buspirone increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. You have to discontinue venlafaxine for at least two weeks before you start treatment with linezolid.

Using bupropion together with linezolid is not recommended. Medications known as monoamine oxidase inhibitors (MAOIs) including linezolid can increase the side effects such as headache, blood pressure elevations, sleep disturbances, tremor, restlessness, nervousness, anxiety, palpitations, and rapid heartbeat. Serious and potentially life-threatening problems can occur. Generally, you must wait at least 14 days after you stop using a MAOI before you start using bupropion; however, for a few MAOIs, the wait can be as short as 24 hours. Check with your doctor before you start using bupropion if you have been receiving linezolid.
Also, Zyvox interacts with pickled food & sauces, aged cheese & improperly stored meat.

Complete blood counts should be monitored weekly in patients who receive linezolid, particularly in those who receive linezolid for longer than two weeks. If the concomitant serotonergic agent is withdrawn due to symptoms of Serotonin syndrome, discontinuation/withdrawal symptoms might be observed.
Wish your husband a speedy recovery!
Answered: Thu, 28 Feb 2013
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Psychiatrist Dr. Seikhoo Bishnoi's  Response
Dec 2014
Hello dcreel
Welcome to HCM

Zyvox is a medicine that is used in a lot of infections. It is comparatively safer drug but it has week Mono Amine Oxidase properties.
So it is not advisable to take zyvox with conventional antidepressants like TCAs, MAOIs etc.
It also increases the concentration of SEROTONIN, and Fluoxetine which is a SSRI and Venlafexine which is a SNRI drug, and also Buspirone, Bupropion which also increases the concentration of Serotonin. So there are very high chances that Serotonin Syndrome may occur in your husband if Zyvox would be given with these medicines.

So as per my opinion kindly avoid giving zyvox with these medicines and visit your psychiatrist for necessary adjustments in dosing of drugs.

Hope I cleared your doubt.
Take Care
Answered: Thu, 28 Feb 2013
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