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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Had bad fever, sinus infection, ESR high. Serum Protein Electrophoresis high. Should I be concerned?

Serum Protein Electrophoresis - Hight Beta Fraction 3 years ago I had bad fever and had high ESR rate, the hematologist thought ER doc was silly for ordering ESR when I had fever and sinus infection (sinusitis) . I was checked for autoimmune disease, liver, kidney, diabetes, protein, cbc and had ct scan. All were normal. However my hematologist ordered Serum Protein Electrophoresis and showed I had these results below. He said he was not concerned by result. I feel fine, no pain, etc..I am only 31. I stumbled on test results while cleaning and became obsessed with High result. After fever and infection was gone, my ESR returned to normal but I never tested for SPEP test again. Here are the readings Doctor: Serum Protein Electrophoresis total protein 8.0 (5.7-8.2) albumin 4.11 (2.37-4.57) alpha 1 - 0.39 (0.24-0.56) apha 2- 1.11 (0.54-1.13) beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen gamma 1.31 (.055-1.57) a/g ratio 1.1 (1.1-2.5) monocional region 0.0 protein electroporesis interp. (no paraprotein detected) Immunofixation Keppa free light chain 16.3 (0.33-19.4) lambda fre lighr chain 13.4 (5.7-26.3) kappa/lamba ratio 1.2 (0.3-1.7)
Mon, 18 Nov 2013
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Diabetologist 's  Response
Dear sir

Welcome to healthcare magic

After completly analysing your case, I can notc2 in the event of chronic infection, the counts will be raised and Esr and crp will be raised too.

Yes of course it is a matter of concern, you should give immediate attention for it

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