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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Glanzmanns thromboaesthnia, cold, runny nose. Will cetirizine hydrochloride or another anti-allergic drug be useful?

Dear Dr. My Son has Glanzmanns Thromboaesthnia, a few days back he has caught cold with a bit of runny nose , is it advisable to give him Anti Histamine like cetrzine Hydrochloride[Relent, Alreid], as it might cause nose bleed also, Please suggest any other anti allergic which do not cause nose bleed. Regards Ankur
Wed, 7 Nov 2012
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Allergist and Immunologist 's  Response
Hello Ankur,
You have asked quite a difficult yet pertinent question.
The GPIIb/IIIa def is functional, and can affect platelet function, and as far as studies are concerned with platelet and antihistamines it is usually a decrease in number (though rare).
Fexofenadine is a long acting 2nd generation antihistamine and the SPC of fexofenadine does not mention any such platelet problem.
You are advised to discuss with your Haematologist if still in doubt.
Thanks.
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General & Family Physician Dr. Debraj Jash's  Response
Hi,
Thanks for query. Glanzmann's thrombasthenia is due to functional deficiency of GPIIb/IIIa. It may cause mucosal bleedind spontaneously or due to precipitating factors. Local nasal decongestants may increase the chance of nasal bleeding. Cetrizine may rarely precipitate nasal bleeding in Glanzman's thrombasthenia. I have gone through extensively through the literatures and found that 2nd generation antihistaminics such as desloratidine, loratidine, fexofenadine may be given safely. Your son may also use fluticasone-azelasine nasal spray one puff twice daily. But , you should better consult a haematologist before starting these medication.Hope, I satisfied your queries.
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Glanzmanns thromboaesthnia, cold, runny nose. Will cetirizine hydrochloride or another anti-allergic drug be useful?

Hello Ankur, You have asked quite a difficult yet pertinent question. The GPIIb/IIIa def is functional, and can affect platelet function, and as far as studies are concerned with platelet and antihistamines it is usually a decrease in number (though rare). Fexofenadine is a long acting 2nd generation antihistamine and the SPC of fexofenadine does not mention any such platelet problem. You are advised to discuss with your Haematologist if still in doubt. Thanks.