Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
133 Doctors are Online

Glanzmanns thromboaesthnia, cold, runny nose. Will cetirizine hydrochloride or another anti-allergic drug be useful?

Dear Dr. My Son has Glanzmanns Thromboaesthnia, a few days back he has caught cold with a bit of runny nose , is it advisable to give him Anti Histamine like cetrzine Hydrochloride[Relent, Alreid], as it might cause nose bleed also, Please suggest any other anti allergic which do not cause nose bleed. Regards Ankur
Asked On : Wed, 17 Oct 2012
Answers:  2 Views:  53
Report Abuse
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Medical Topics
Allergist and Immunologist 's  Response
Hello Ankur,
You have asked quite a difficult yet pertinent question.
The GPIIb/IIIa def is functional, and can affect platelet function, and as far as studies are concerned with platelet and antihistamines it is usually a decrease in number (though rare).
Fexofenadine is a long acting 2nd generation antihistamine and the SPC of fexofenadine does not mention any such platelet problem.
You are advised to discuss with your Haematologist if still in doubt.
Answered: Sun, 4 Nov 2012
I find this answer helpful
General & Family Physician Dr. Debraj Jash's  Response
Thanks for query. Glanzmann's thrombasthenia is due to functional deficiency of GPIIb/IIIa. It may cause mucosal bleedind spontaneously or due to precipitating factors. Local nasal decongestants may increase the chance of nasal bleeding. Cetrizine may rarely precipitate nasal bleeding in Glanzman's thrombasthenia. I have gone through extensively through the literatures and found that 2nd generation antihistaminics such as desloratidine, loratidine, fexofenadine may be given safely. Your son may also use fluticasone-azelasine nasal spray one puff twice daily. But , you should better consult a haematologist before starting these medication.Hope, I satisfied your queries.
Answered: Tue, 6 Nov 2012
I find this answer helpful
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]


Loading Online Doctors....
© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor