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Feet pain, high CRP, ESR normal, prescribed HCQS and calcium. Something to worry about?

Hi, I have been diagonised with TB since Nov 2011. I have been taking ATT regulary and had put significant weight. During March 2012 this year, the doctors increased the dosage of TB ATT, there were couple of enlarged lymph nodes in superaclavicular region. So, they started me Streptomycin ,Zanocin,PZA(1500),INH(300),Rifamicin(600),Ethambutol(1200). In June, the CT scan confirmed the nodes are gone, so the dosage was reduced to only INH,Rifamicin & Ethambutol. But in the past 3 months, I have mild feet pain(esp in the right). Doctors asked me to check for CRP , it was 61, ESR was normal. So they started me with HCQS and Calcium tab for 15 days, I feel kind of better but still the pain exist in the morning. Sometimes I get confused, is it the joints/Bones or nerves. Last week a repeat CRP was ordered, it came down to 6.1 but still I am having feet pain. Is it something I need to worry about? I am thinking the pain is because of TB drug side effects, so kindly advice me what could be the actual cause and my course of action. Thanks GK
Tue, 23 Apr 2013
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Pulmonologist 's  Response
Hi gokulkannank,
Thanks for visiting HCM.
If the tuberculosis is a drug sensitive one 6-9 months of treatment is adequate.
Now regarding the side effects, joint pain can be due to hyperuricemia caused by pyrazinamide. so testing for serum uric acid level is a good step and if it is raised, simple analgesics like paracetamol or ibuprofen usually help. But if symptoms persists then drugs like allopurinol needs to be taken.
Isoniazide causes peripheral neuropathy with burning sensations in feet or feeling of pins and needles. This symptom can be alleviated by taking tablet pyridoxine along with this medication.
CRP is a good test but serum uric acid would have been better one as far as side effect of tubercular medication is concerned..

Best wishes
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