What is the cause for his severe edema? Is it because of the heart failure
, kidney failure, liver failure
to any drug? Unlikely that increased dose of Lyrica
would induce allergy as he's been taking that from the begining. Just make sure his edema is treated by a physician by personally seeing him. Any kind of additional infection in his concomitant illnesses would make him feel feverish and chilly. Do see a physician before he develops frank fever and the infection spreads faster. All the very best.