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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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FSGS due to immune disorder, difficulty in urinating, low IG, eases with Cellcept therapy. Could cellcept be causing this?

Hi. My name is Lucia and I m from Croatia. I m 20 years old and 3 years ago I was diagnosed with Focal Segmental Glomerulosclerosis (FSGS)- Nephrotic syndrome . With two biopsies of kidney it was confirmed that FSGS was caused by immune disorder . And everyone were asking themselves how to stop progress of kidney failure. My whole body was swollen, proteinuria was 54 gram per liter so I couldn t urinate, vomiting and sleeping were my everyday occupations. Of terapies, I was going from Medrol( methylprednisolone ), Cyclosporine(Sandimune), Endoxan (3 Bolus Therapies) to CellCept ( Mycophenolate Mofetil ). None of it worked except Cell Cept( but only after I was done with 3 times of plasmaferesis with Human normal Albumines 20%). Now, I am stable, my blood is ok, proteinuria is 1 gram per liter. Cholesterol is now normal, immunological findings are ok, except Immunoglobulin G which is very low. I suppose it is because of Cellcept, but am I right? If yes, will it ever be normal, and if no, do you have any answer?
Wed, 19 Dec 2012
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Nephrologist 's  Response
hi lucia,

FSGS is a autoimmune disease characterized by proteinuria. if u are OK with celcept- the proteinuria is

if there is relapse with high proteinuria then you will reguire further newer agents for treatment.

hope this helps
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FSGS due to immune disorder, difficulty in urinating, low IG, eases with Cellcept therapy. Could cellcept be causing this?

hi lucia, FSGS is a autoimmune disease characterized by proteinuria. if u are OK with celcept- the proteinuria is if there is relapse with high proteinuria then you will reguire further newer agents for treatment. hope this helps