I had a bovine dvalve replacement in Oct. 2012. I am not asked which medications did I find most effective prior to that operation. I was taking diazide, metoprolol and lotrel (amlodipine combo) at that time. My feet had become balloon shaped and I felt the lotrel may have caused that. On the other hand the suggestion of lisinopril worries me because I am unaccustomed to it's effect. I have recently re-started the diazide but have racing heart periodically. For that reason I lean toward Metoprolol. Would you think lisinopril a better choice. (I will not be going back on lotrel until other meds are in place, in order to see if it swells the bottoms of my fee.) I am 60 and diabetic.