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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does the side effect from Methotrexate cause strong odor in urine?

I am on methotrexate .5 ml injections for rheumatoid arthritis and have noticed that I have had a strong odor eminating from either my urine or from my vaginal area. Could this be a side effect of the methotrexate? I did not have this odor before I began taking this medication.
Tue, 15 Oct 2019
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General & Family Physician 's  Response

Methotrexate is a drug that may affect the immune system so it increases the risk of infections. In your case, because you have a strong smell in the urine, I would recommend you to have a visit with the doctor and possibly a urinalysis to rule out urinary infection.

If a urinary infection is present, the doctor will have to prescribe antibiotics. Also, the doctor may consider doing some blood tests to make sure that your white blood cell count is normal.

I hope this answers your query.
I remain at your disposal for further medical assistance.

Dr. Antoneta Zotaj
General and Family Physician
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