on the WebMD site I found this information under the topic Prazosin for PTSD: Prazosin can be taken safetly with other PTSD medicines, such as antidepressants, but not with trazodone. Taking prozasin with trazodone can cause the rare side effect of priapism. this is an erection that doesn t go away, which can cause serious health problems. But when I check the drug interaction feature on WebMD, putting in the two drugs Prazosin and trazodone, it says there are no adverse interactions. Is it, or is it not, safe for a male to take these two medications together?