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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Spider Bite Like Round Marks On Leg Indicate Lupus?

My daughter is 27, she had blood test done because of what we thought was a spider bite plus two small round marks on her leg . Test said she was a carrier for lupus .. What other test can be taken . Will get second opinion at Cedar Sinai.. Very worried parents she s just about to finish college and start her new career in teaching.. Any answers would be greatly appreciated . Thank you
Sat, 26 Nov 2022
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Anesthesiologist 's  Response
Hello,

The following are few symptoms of systemic lupus erythematosis:
1) Constitutional (eg, fatigue, fever, arthralgia, weight changes)
2) Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis)
3) Dermatologic (eg, malar rash, photosensitivity, discoid lupus)
4) Renal (eg, acute or chronic kidney failure, acute nephritic disease.

Diagnostic considerations are as follows:
1) Antiphospholipid antibodies
Anti-cardiolipin antibodies or Anti-β2GP1 antibodies or Lupus anticoagulant
2)Complement proteins, low C3 or low
3) SLE-specific antibodies, anti-dsDNA antibody or anti-Smith antibody

Scoring system is given as per EULAR/ACR classification. The following tests are necessary:
Complete blood count (CBC) with differential
Serum creatinine
Urinalysis with microscopy
C-reactive protein (CRP) or Erythrocyte sedimentation rate (ESR)
Complement levels
Liver function tests
Creatine kinase assay
Spot protein/spot creatinine ratio

These battery of investigations along with various antibody tests are considered standard diagnostic regimen in SLE or lupus. SLE often waxes and wanes in affected individuals throughout life, and features of the disease vary greatly among individuals. The disease course is milder and the survival rate higher in persons with isolated skin and musculoskeletal involvement than in those with kidney disease. Please do consult a rheumatologist for classification of grade of lupus and initiating treatment.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Pallavi M., Anesthesiologist
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Does Spider Bite Like Round Marks On Leg Indicate Lupus?

Hello, The following are few symptoms of systemic lupus erythematosis: 1) Constitutional (eg, fatigue, fever, arthralgia, weight changes) 2) Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis) 3) Dermatologic (eg, malar rash, photosensitivity, discoid lupus) 4) Renal (eg, acute or chronic kidney failure, acute nephritic disease. Diagnostic considerations are as follows: 1) Antiphospholipid antibodies Anti-cardiolipin antibodies or Anti-β2GP1 antibodies or Lupus anticoagulant 2)Complement proteins, low C3 or low 3) SLE-specific antibodies, anti-dsDNA antibody or anti-Smith antibody Scoring system is given as per EULAR/ACR classification. The following tests are necessary: Complete blood count (CBC) with differential Serum creatinine Urinalysis with microscopy C-reactive protein (CRP) or Erythrocyte sedimentation rate (ESR) Complement levels Liver function tests Creatine kinase assay Spot protein/spot creatinine ratio These battery of investigations along with various antibody tests are considered standard diagnostic regimen in SLE or lupus. SLE often waxes and wanes in affected individuals throughout life, and features of the disease vary greatly among individuals. The disease course is milder and the survival rate higher in persons with isolated skin and musculoskeletal involvement than in those with kidney disease. Please do consult a rheumatologist for classification of grade of lupus and initiating treatment. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Pallavi M., Anesthesiologist