Hi Doctor, I am writing this long scenario of how my blood sugar run high- with hopes that you may advice a better approach and this might even help another diabetics who may be going through this too. I am what they call a Brutal Diabetic . I am a 29 yr old female and have been a Type I diabetic since I was 12. I was put on a Medtronic Minimed a Insulin Pump a couple of years ago after my sugars have been out of reach to make them normal years. I have had my share of ups and downs with or without the pump-but on the positive side thanks to my pump and it s sensor -at least now I can visually see where I am with my sugars rather than walking around clueless until I do a glucose meter check. Of course, I do check my accurate glucose by meter and calibrate when the pump alerts me to. I m normally within my range which is 80-140 fasting 40% of the time of my normal days. But lately, my fasting sugars run high starting at 12a.m til mid day. For example today-I woke up with 448 and I battled trying to cure my high sugars to bring them back to normal, by doing all the following alternatives: drinking water, check my glucose readings every hour to see if its dropping, taking 5 units of insulin by shot (im on Novolog), set a temporally basal on my pump to .90 units per hour, and even continued taking my bolus after each meter check. I am very exhausted and this has been happening for more than a week. After the morning hurdles, the rest of my day are not as bad, because I have more control of what I eat and I m more alert to see my sugars compared to when I m sleeping at night. My carb ratios is 15 BG Units and my sensitivity is 70. I need help desperately: my high symptoms make me fatigue, tired, dry mouth, extreme blurry visions, neck and shoulder aches, and irritable. I already know I m losing protein in my urine so I don t even bother checking my keytones. I am very athletic and weigh 140 so nothing is wrong with obesity- if I enjoy a sweet treat I definitely cover my carb bolus intake so this doesn t happen. I ve been feeling a little sick: maybe a summer cold-so last night I drank an 8 ounce class of orange juice for Vitamin C and of course I checked my BG first and it read 190 before bedtime- so I took what my pump calculated for the OJ which is 35 units of insulin per serving. The aftermath lead me to wake up with a depressing 448 BG reading and raising. I can t wait for my sugars to be normal again so I can get back to my workout schedule but when its high like this I was advised not to do so, until my sugars are at least in the 200 s. Diabetes is a struggle for me, I learn everyday from my BG readings and I try to improve the following day. But, when I wake up with highs it s a much harder challenge to beat because the diabetes has more control. I completely understand why doctors like diabetics to start on a right foot at fasting in mornings-because it gives us a jump start grasp on how the rest of the day will go...better sugars better control of life. That is my everyday dream Thank you in advance!! Please help: Now that you have an idea of my high sugar ellipsoid, I m I doing something wrong? Or could I be battling and infection causing my sugar highs? Does depression or stress cause high sugars?