HI, I understand your concern. Cough & cold medicines with anti histaminic drugs/ some antibiotics which should be avoided in early pregnancy. HOwever a short course of these medicines can not have bad effect. So no self medication is advocated in early pregnancy. It is better to prevent any such health issue- which would need medication/ to manage them with home remedies, herbal medicines in early pregnancy . BUt if there is sever infection, doctor chooses safer drugs. As for your wife is concerned, she has taken cough medicines before diagnosing pregnancy & you are worried for that.It s good, that she has stopped them after diagnosis. Please consult the doctor about safety of medicines she has taken. Usually we avoid giving harmful medicines to woman who expects pregnancy ( in 2nd half of her cycle ). Please don t worry, inform your treating doctor about the fact.. so that care can be taken to avoid/ exclude/detect any bad effect in follow ups ( specially anomaly scan in 5th month) Medicines like folic acid/ Vitamin E/ omega 3 fatty acids /B complex do have role in preventing bad effects of the medicines. Doctor would advise it as per need, Thanks.