Hi, Ciprodex contains antibiotic ciprofloxacin and steroid Dexamethasone. Hence there is a possibility of aggravation of infection if the offending organism is not sensitive to ciprofloxacin; hence need to be discontinued. Ideally, ear discharge should be sent for culture & sensitivity to determine the causative organism and its sensitivity pattern, so that a suitable antibiotic could be started. Pending culture report empirically suitable antibiotic ear drop (preferably aminoglycoside gentamicin to cover potential pseudomonas infection) should be started. Ciprofloxacin ear drop may sometimes cause a local reaction to say transient irritation, burning, stinging, inflammation, angioneurotic edema, dermatitis. Consult your ENT specialist. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Tushar Kanti Biswas, Internal Medicine Specialist