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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Seroquel affect serotonin in the brain?

Does seroquel affect serotonin in the brain, and if so, how? I ve begun taking a small dose of 5-HTP which is highly touted for passing the blood brain barrier and strengthening the serotonin levels. My body is not receiving this well and I suspect my even small dose of seroquel is why.
Sat, 3 Sep 2016
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Internal Medicine Specialist 's  Response
Thanks for your question. You are correct: 5-HTP is a precursor of serotonin (5-hydroxytryptamine) and boosts serotonin levels in the Central Nervous System (brain). Seroquel inhibits multiple neurotransmitter receptors in the brain, including serotonin types 1 and 2 (5-HT1A and 5-HT2), to effectively lower serotonin levels in order to exert the desired psychiatric response of this medication. Why were you prescribed the 5-HTP? It seems to counteract the effect of the Seroquel... and when you say your body is not receiving it well, what does that mean?
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Does Seroquel affect serotonin in the brain?

Thanks for your question. You are correct: 5-HTP is a precursor of serotonin (5-hydroxytryptamine) and boosts serotonin levels in the Central Nervous System (brain). Seroquel inhibits multiple neurotransmitter receptors in the brain, including serotonin types 1 and 2 (5-HT1A and 5-HT2), to effectively lower serotonin levels in order to exert the desired psychiatric response of this medication. Why were you prescribed the 5-HTP? It seems to counteract the effect of the Seroquel... and when you say your body is not receiving it well, what does that mean?