Hi and welcome to Healthcaremagic. Thank you for your query. I am Dr. Rommstein, I understand your concerns and I will try to help you as much as I can. Well,there are no some specific interactions but Methotrexate is agressive medication for itself and all these symptoms may be side effects of metotrexate alone,not related to interactions so you should reconsider methotrexate. I hope I have answered you query. If you have any further questions you can contact us in every time. Kindly regards. Wish you a good health.