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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Effexor-XR Of A Higher Dose Have Any Side Effects?

I have been on Effexor xr for aproximatly 12 yrs. I have dealt with depression and anxiety since 1986. have been doing pretty good until about 2 mo s ago started feeling a lot of anger,frustration mood swings.then the most recent issue not being able to sleep waking up 2,3,4, times a night. or just insomnia. my doctor has increased my dose from 300mg daily to 450 daily. My concern is that this is too much I thought maximum dose was 375. am I wrong to beconcerned about this?
Mon, 19 Oct 2015
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Psychiatrist,  's  Response
the main concern of going to higher doses of Effexor XR would be the possible increase in blood pressure and heart palpitations. otherwise, if you tolerate the medication well, you should be fine. another concern you should have is that if you decided to change the Effexor and try something else, the transition of tapering you down from such a high dose to another antidepressant would be very difficult because you would most probably go through uncomfortable withdrawls side effects.
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Does Effexor-XR Of A Higher Dose Have Any Side Effects?

the main concern of going to higher doses of Effexor XR would be the possible increase in blood pressure and heart palpitations. otherwise, if you tolerate the medication well, you should be fine. another concern you should have is that if you decided to change the Effexor and try something else, the transition of tapering you down from such a high dose to another antidepressant would be very difficult because you would most probably go through uncomfortable withdrawls side effects.