My husband started taking desipramine 10 mg three times a day, 6 days ago. treating diabetic neuropathy pain in his feet, it replaced Cymbalta 60 mg that he had been taking for 3 weeks and before that he had been taking Zoloft for about 18 years. He also is a heart patient with severly reduced ejection fraction of 21 %. AFTER STARTING THE DESIPRAMINE, He first started having increased heart rate raising from his usual between 75 and 85 to 99 to 120, and now he is complaining of a strange medicine like, vapor like smell. And is weak feeling.