I ve been taking Cipro and Prednisone because my De. prescribed them-- cipro for herpes and prednision for sudden swelling of one foot. When I read about the risk or tendon rupture (I m , I asked him at follow up appointment, and he said/ I ve had years of medical training, study journals at night (so don t question my judgement). He s usually very patient and kind! I then called the Advice Nurse for my plan ,and she wouldn t comment, but recommended seeing another dr. within 24 hr. for another opinion. that sounds very stressful and 2nd dr. would prob. back up his colleague, esp. since I m OK for now. So, is there anything I can do to prevent tendon damage or rupture? I stopped the Pred.(10 mg 1/day) today (have 2 and have 15 Cipro tabs left. The cold sore is cleard up and foot swelling is gone. Thanks for any help.