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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Carvedilol Cause Dementia And Confusion?

My 90 year old Dad recently was in the hospital with pneumonia. One of the medications he routinely took WAS propranolol for essential tremors. The hospitalist changed his medications to carvedilol for blood pressure & gabapentin for the tremors. My Dad is now back at the home, but acting very delusional - making up stories & being confused about reality. He was also on several antibiotics for the pneumonia and he takes trazodone at bedtime - he thinks it is for sleeping, but it is really for depression. Could this change in medicine have brought on this increased confusion, or worsened his dementia, or is something else possibly happening?
Thu, 23 Nov 2017
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General & Family Physician 's  Response
carvedilol is an intermediate lipophilic beta-blocker which causes fewer symptoms of the central nervous system compared to propranolol which is a high lipophilic beta-blocker. Beta-blockers with high lipophilic can cross the blood-brain barrier and cause insomnia and confusion. I think the dementia is probably caused by something else.
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Does Carvedilol Cause Dementia And Confusion?

carvedilol is an intermediate lipophilic beta-blocker which causes fewer symptoms of the central nervous system compared to propranolol which is a high lipophilic beta-blocker. Beta-blockers with high lipophilic can cross the blood-brain barrier and cause insomnia and confusion. I think the dementia is probably caused by something else.