Dear, I have read your question and I understand your concern regarding your husband s health. Firstly, Benadryl does not interact with Atorvastatin and thus cause adverse side effects. This is not a matter of concern. At the same way, itching is not a side effect of Atorvastatin. From what you describe, the fact that your husband s platelets are low, makes me agree with your MD in thinking that this is a Hematologic condition. Often, blood disorders are associated with itching, and they need a specialist to make a further in-detail examination. Please, do not stop any med in the meantime, because, as I explained above, they are not causing the itching and your husband needs them. I hope I have answered your question. I wish you and your husband good health! Manoku Eni M.D.