Hello, crhand.ch, I see that your diagnosis of Crohn s disease was very recent and you have been put on Pentasa as part of the treatment. I am not sure if you know how much of your intestines are affected by Crohn s. Typically it affects the last portion of the small bowel and the beginning of the large bowel, the area called the ileo-cecal junction. But the disease can affect any part of the digestive tract from mouth down to the anus. Maroon colored stools are suggestive of colon involvement, Crohn s Colitis. If your type-1 diabetes is well controlled, the diarrhea is probably not from that, a condition called Diabetic Enteropathy due to lack of digestive enzymes from your pancreas. I am assuming you are on adequate dose of Pentasa. From your response, this has not been effective. It is possible that you could try other Mesalamine products such as Asacol and see if the response is any better. But, I think because of significant weight loss and presumably blood loss, Crohn s seems to be active despite your therapy. There is locally acting steroid called Budesonide which can bring on remission if the mesalamine is not working. A 9mg. dose daily can be effective. There are other ways of treating by using what we call Immunomodulator drugs such as 6-mercaptopurine or Azathiprine. There are known side effects from this type of drugs. Next is called Biologicals which are highly effective. The most commonly used drug is Infliximab given as injection. The best thing I would advice you is to see a gastroenterologist who can asssess your situation properly and select appropriate treatment that I have briefly mentioned above. I wish you well.