Hello, Thanks for your post. Renal parenchymal disease in diabetic patient is common and may eventually lead to kidney failure. Creatinine is toxin produced in our body it can not be excreted properly by kidney when it is damaged leading to high levels of creatinine in blood and it may present with skin itching and swelling. Recommended aim is to control sugar levels by dietary changes and medication. Foods rich in carbohydrate and proteins are avoided. Skin scratching should be avoided. You are advised to visit diabetologist and nephrologist for further management. Hope it helps. Take Care!