Dear Ma am, Sorry to hear about your husband s problem. Recurrent thyroid cancer with metastasis can be challenging to treat but radioiodine can be given in such patients and sometimes it can cause regression of the metastasis. Naxaver (sorafenib) is a drug which is being used to treat unresponsive thyroid cancers and has been shown to have good effect in clinical trials. The side effects of sorafenib are skin rash, hand-foot skin reactions, diarrhea, and hypertension. Hoping for the best.