Dear friend .. Thanks for your query to Healthcare Magic I would say that atpresent crohns disease is treated by symptomatic management , As you said scientist are working out in the inflammatory bowel disorder, and says that it originate from specialised intestinal cell type called Paneth cells. Researchers also found that defective autophagy might lead to Crohn s disease via an inability to remove bacteria within the cells. However, the new research reveals that autophagy plays a role in keeping in check the inflammatory function of the unfolded protein response, which is activated when the endoplasmic reticulum (ER) is stressed. Rapamycin is under trial to treat autophagy and to cure Crohns permanently . Regards Dr.J.Kingson John David