hello friend, thyroid diosrder can lead to irregular periods / but as you are on supplements, obesity and polycystic ovarian disease is more likely to cause irregular cycles Weight reduction if you are obese is the most important management for which you can adopt an exercise pattern Metadose and benforce m are metformin (later one has benfothiamine too which is likely to decrease your androgen levels and address your weight issues to some extend- gastritis is the only usual side effect associated. Krimson is E/P combination which will regularise your cycles. No signifiacant side effects except weight gain, pedal edema and mild elevation of liver enzymes