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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could severe mood swings be due to cortisone injection?

Hi. I had a cortisone shot in my knee a week ago. I m having some systemic effects (2-3 days of facial flushing, strange mood). The flushing has stopped, but I notice I m a bit irritable. I m usually easy going and generally unflappable. I ve actually noticed my change in mood and wondered where my usual self is. Could this be related to the injection? If so, how long will it be in my system? Thanks
Mon, 23 Mar 2015
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General & Family Physician 's  Response
Dear Patient,

yes the cortisone can have sideeffects on the mood as you are describing. After the shot it will be in your body for about 1-2 weeks. However, these mood changes should be over soon since the concentration decreases, so there is a very good chance you feel better soon. Hope this is helping you , if you have any clarificatons you can get back to me, if this was helpful please kindly rate my answer. Best regards
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