I started using the estring prescribed by my gynecologist in mid February. I had my annual physical last week - everything was perfect except for abnormally high, critical liver enzymes. I have never had any liver problems in the past. A second set of labs verified the results. I tested negative for Hep A,B, and C and my platelets, cdc, ana all were normal. I had an abodminal sonogram this past Friday - all normal. I did remove the estring last Friday and my urine has become lighter in color (no change in water intake). Could there be a link between the estring and my extreme liver enzyme levels? Going back to give blood in a few weeks.