My friend had PCOS a long time ago, and SLIGHTLY high blood sugar... after testing, the doctor said, we can knock out both with metformin, and she went on it in 06). PCOS disappeared and little changed medically... and then she became pregnant very soon after that. With that pregnancy she was diagnosed with gestational diabetes and went on insulin. After that(Mid 07) she went back to metformin... in late 2009, she was still on metformin but doing great. She went off metformin in (Sept. 09) and her blood sugars were great... never over 115, usually 100 or lower, which she had previously been told she could never do again because once you have glucose intolerance your always diabetic . ( I should clarify this by stating she has NEVER been diagnosed type 2, she was found to have impaired glucose tolerance) Well everything was peachy until this august, early September... after a year of good health her blood sugar started rising... avg of like 140 to 150 and she was getting lethargic, so she had to go to the clinic...(no insurance) Once she revealed she had been on metformin(a year ago) the doctor prescribed her more and said he was sure it was just early diabetes... then gave an A1C on which she got 5.7... She has NEVER had an A1C over 7... either way the doctor didn’t care to figure more out... well now we re in the spot where she feels awful and her blood sugar is even HIGHER after taking metformin for a few months again. (160 to 190) So this leads me to ponder a few things... 1. If she is diabetic, how was she super healthy for a year, scored an A1C of 5.7 and didn’t even feel to sick, mainly just lethargic when her blood sugar began to rise..? 2. If she isn’tt diabetic, is taking the medicine causing unnecessary problems like that lactic acidosis (lf I m not mistaken, metformin is known to cause). 3. Is there a chance its thyroid related?. 4. What vitamins do you recommend for this sort of issue? Food intake: Shes make a lot of our own food, some even from what we got out of our garden. Water intake: She doesn’t usually drink as much as she should, she says she just never feels thirsty, and hasn t since child hood. Although she is working on drinking anyways... Exercise: She is not overly active, but not a total bum.. so moderatish( we have 3 kids to take care of) Oddities: as I stated, Sarah has never really felt thirsty, also strangely, on metformin she is now craving MORE food, especially sweets, even though metformin is used as an appetite suppressant... this side effect was not present when she was on metformin in the past. Any advice on this issue would be much appreciated. Thank you very much. Kristin