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Cholesterol, triglyceride and hemoglobin level. On doxycycline. Related?

Does Doxycycline efffect cholesterol and triglyceride levels and hemoglobin A1C levels?

For the past 10 years my total chloresterol level has ranged from 150-160 and triglycerides from 100-110. A1C levels range from 5.7 to 6.1, and were at 5.7 in December 2012.

I started on Doxycycline in January for Rosecea. My quarterly blood tests came back with chloresterol at 185, triglycerides at 170 and A1C at 6.3. The previous 6 tests scores for each test were trending slightly downward and now I have a spike.
Asked On : Thu, 18 Apr 2013
Answers:  2 Views:  856
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General & Family Physician 's  Response
Hi and thanks for the query,
It would be very unlike in this particular situation situation attribute any changes in Serum Glycated hemoglobin and triglycerides to Doxycycline. Serum HbA1c levels give ab approximate behaviour of blood glucose for over a period of three months. In your case, with no history of liver disease, it would be very unlike that this drugs metabolism changes these parameters, provided also that we do not have any signs of acute liver damage described.
Its worth noting that results you present are all still within normal limits, and small changes should normally be observed during measurements, due to normal physiologic variations and tests that are used. Remember the tests or reagents in testing usually differ and the techniques might also differ. It is there fore not unusual to note different results.
However, when results are actually abnormal, it is necessary to consult your treating physician, for a clinical assessment and control of the specific tests.
Thanks as I hope this helps,
best regards,
Luchuo, MD.
Answered: Thu, 18 Apr 2013
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General & Family Physician Dr. Bruce Kinney, DO's  Response
Hello, and welcome to HCM!

Doxycycline is not associated with elevated cholesterol or blood sugar: (

The changes in your blood tests should be taken seriously, as high cholesterol and diabetes will put you at greater risk of cardiovascular disease (including heart attacks, strokes, and others). However, the increases you have seen over a one year period could certainly be caused by increasing age as well poor diet. I would recommend meeting with your doctor to discuss changes to your diet that could help ensure that your blood tests are again normal when they are checked next year.

Finally remember that the most important number that we look at in cholesterol (or lipid) panels is the LDL (also known as the 'bad' cholesterol), not the triglycerides or total cholesterol. Total cholesterol is no longer considered a reliable way to tell if a patient has health risks from cholesterol.

I wish you the best of health, and thank you for posting on HCM.
Answered: Thu, 18 Apr 2013
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