Hi,Thanks for posting your query, The majority of granulomas are the result of an injury to the tissue, particularly as the result of infection. They can occur in the lungs, and their most common cause there is a fungal infection called histoplasmosis. Other conditions associated with granuloma formation include berylliosis, syphilis, sarcoidosis, Crohn’s disease, tuberculosis, Churg-Strauss syndrome, and Wegener’s granulomatosis.

The granuloma that forms as the result of these conditions is generally a calcified granuloma. This type contains deposits of calcium and usually takes time to develop, which means that most have been present in the body for a very long time before they are identified.

Another form is the granuloma inguinale, which is a bacterial infection of the genital area. It's caused by a bacteria called Calymmatobacterium granulomatis, and mostly affects individuals living in tropical and subtropical regions, such as Guyana, Southeast India, and New Guinea. In addition, this sexually transmitted bacteria affects men more often than women, particularly homosexual males. An individual with this disease develops blisters or lumps in the genital region, which ultimately become open sores. RRegards, Dr.Sharmila