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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Taking Dulcolax Along With Golytely Be Safe During Colonoscopy?

Hi, I am going to prepare for a colonoscopy using GoLytely, I am also asked to take 2 tablets of Ducolax without any instructions when to take them. On line I read that sodium bicarbonate (in GoLytely) may interfere with Ducolax. Any advice? (except call your doctor) Regards, Egon
Fri, 13 Nov 2015
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Ayurveda Specialist,  's  Response
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1. Since the said interaction is 'moderately' clinically significant [which means the said combination is usually used under special circumstances [colonoscopy] thus it won't be any major drug-drug interaction.

PS. it is calcium carbonate present in antacids which interfere with dulcolax, since by increasing gastric pH, they may reduce the resistance of the enteric coating of bisacodyl tablets, resulting in earlier release of bisacodyl and gastric irritation and dyspepsia.

2. After taking dulcolax, after you have passed stool then take golytely.
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Can Taking Dulcolax Along With Golytely Be Safe During Colonoscopy?

** 1. Since the said interaction is moderately clinically significant [which means the said combination is usually used under special circumstances [colonoscopy] thus it won t be any major drug-drug interaction. PS. it is calcium carbonate present in antacids which interfere with dulcolax, since by increasing gastric pH, they may reduce the resistance of the enteric coating of bisacodyl tablets, resulting in earlier release of bisacodyl and gastric irritation and dyspepsia. 2. After taking dulcolax, after you have passed stool then take golytely.