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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can severe dehydration lead to insulin resistance?

Hello, I have a question regarding insulin resistance and dehydration. I m a Type 1 Insulin Dependent diabetic. Have been for nearly 16 years. My HA1c was last 4.9% so I keep my numbers extremely regulated. Anyways to the question, can severe dehydration lead to insulin resistance? I have some idea of the physiology but I want to understand it thoroughly. Let me give you the story first so you can maybe give me the walk through of it all especially the dehydration and insulin resistance. So after heavy drinking ( not something I do often at all....) , 6-7 hours of hard alcoholic drinks and no water during this time. I went to sleep woke up the next morning feeling very thirsty, it d been about 18 hours since I had a sip of water. So I drank some, and became nauseous. My sugars kept rising, initially was 192, ended up at 425 before I had to call 911. I was not holding down water.. my glucose was rising, I was taking massive amounts of insulin, somewhere in the 80-100 units of Humalog range. I take ~60 units in a day and this was in a matter of 12 hours probably. And my numbers did not drop. My question is why and whats the physiology behind the insulin not working? Something with the dehydration but Im not quite understand it. Please answer this if you can. Oh and I was not consuming food during this time so the glucose rise was not from carbohydrates. WWW.WWWW.WW
Wed, 14 Nov 2018
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General Surgeon 's  Response
Hello,

A stage of severe dehydration can definitely alter the body's ability to respond to insulin via insulin receptor disturbances and another cellular dysfunction, which requires water at a very large scale.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Bhagyesh V. Patel,
General Surgeon
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Can severe dehydration lead to insulin resistance?

Hello, A stage of severe dehydration can definitely alter the body s ability to respond to insulin via insulin receptor disturbances and another cellular dysfunction, which requires water at a very large scale. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Bhagyesh V. Patel, General Surgeon