Hello, Periodontal disease can include infections that spread. Your system can react with these symptoms if the infection is severe. I do not know the extent of your periodontal disease or treatment provided. Are teeth loose and moving? Have you been placed on medications and have you ever had an allergic reaction to similar medications? Do you have habits such as grinding your teeth? Headaches and migranes can be associated with grinding or clenching your teeth. Often your bite needs adjustment with severe periodontal disease. I would suggest you discuss your symptoms with the dentist that diagnosed your periodontal disease. Toothpaste for sensitive teeth and fluoride rinses can help reduce soreness. You must keep up good dental hygiene. Warm salt water rinses may soothe healing tissue. Proper nutrition and hydration are important. Diet considerations may include a softer diet with reduced acidic, alcohol and spicy content. No smoking. Reduce irritants to your tissue. Pain and anti-inflammatory medications often help with discomfort and healing with periodontal treatments. Your dentist may prescribe a prescription rinse to assist healing and comfort. Thank you for your inquiry. I am available to answer additional questions if you provide additional details on your periodontal condition. I hope you find this helpful and will feel better soon.