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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Decongestant Be Taken Over Amitryptilyn, Topomax?

Hi. I ve got a head cold and am suffering from nasal congestion, runny nose (the mucus is clear) and body aches. I take 25 mg of amitryptilyn at night, along with topomax and a muscle relaxer for headaches. Can I take an over-the-counter decongestant if I am taking these other medications?
Fri, 29 Mar 2019
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General & Family Physician,  's  Response
Hello,

Tricyclic antidepressants like Amitriptyline and decongestants like phenylephrine do have a serious interaction that may unpredictably alter the effect of the phenylephrine.

While you would probably be alright if you did take a decongestant, I would recommend you use a nasal steroid instead, which would probably be more effective for your nasal congestion and runny nose, and does not have any serious interactions with your other medications.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Aaron Branch, General & Family Physician
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Can Decongestant Be Taken Over Amitryptilyn, Topomax?

Hello, Tricyclic antidepressants like Amitriptyline and decongestants like phenylephrine do have a serious interaction that may unpredictably alter the effect of the phenylephrine. While you would probably be alright if you did take a decongestant, I would recommend you use a nasal steroid instead, which would probably be more effective for your nasal congestion and runny nose, and does not have any serious interactions with your other medications. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Aaron Branch, General & Family Physician