Hello Thanks for query .Your boyfriend has developed peeling of skin over shaft of the penis after applying hair removal cream . This is mostly due to allergic reaction to hair removing cream . He needs to take broad spectrum antibiotic like Cefixime and anti inflammatory drug like Diclofenac twice daily .along with topical steroid cream like Betnovsate for local application twice daily. Ensure he washes his genitals with warm water twice daily. Ensure to avoid sexual encounters till it heals up completely. Since both of you are known to each other and have in sexual relationship since a long time and absence of any symptoms suggesting STD there is no possibility of STD . Dr.Patil.