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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Oxycodone-Acetaminophen And Diazepam Be Taken Together?

my doctor changed my medication yesterday and I am confused as to the safety of the combination.(I am in my third week post-op total knee replacement. I am also dealing with L3 nerve pain and sciatic nerve pain in the same hip and leg.) Doctor discontinued my muscle relaxer,IC Methocarbamol and replaced it with IC Diazepam 5mg, 1 tablet every 12 hrs. I am also taking IC Oxycodone-Acetaminophen 10-325,1 to 2 tablets every 4-6 hours, and it scares me to take two addictive drugs. I am also on IC Gabapentin 300 MG 3X s a day. I talked with her assistant yesterday and she didn t clear up my concern. Thank you for any help you can offer.
Tue, 12 Sep 2017
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General & Family Physician 's  Response
HI, thanks for using healthcare magic

Fortunately the oxycodone and diazepam , though as you said are both addictive, they do not act to increase the addictive potential of each other..

If the diazepam is only used for a short period of time then tolerance and dependence should not occur.
Diazepam is also long acting, so there is less risk of dependence

I hope this helps
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Can Oxycodone-Acetaminophen And Diazepam Be Taken Together?

HI, thanks for using healthcare magic Fortunately the oxycodone and diazepam , though as you said are both addictive, they do not act to increase the addictive potential of each other.. If the diazepam is only used for a short period of time then tolerance and dependence should not occur. Diazepam is also long acting, so there is less risk of dependence I hope this helps