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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Omez Be Safely Taken For A Long Duration?

I am 56years old.suffering burning sensation in my throat and stomach.10 years back I suffered from deodenal ulcer. I took Omez 20 .1tab for 15 days but symptoms persist. I started to take aciloc 150 twice a day from yesterday. How long I can continue this drug.
Wed, 30 Jan 2019
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Internal Medicine Specialist,  's  Response
Hello,

Long-term acid suppression, especially with PPIs (Proton Pump Inhibitors e.g. Omeprazole), has been associated with a higher incidence of community-acquired pneumonia as well as community and hospital-acquired Clostridium difficile–associated disease.

Long-term use of PPIs is also associated with the development of hip fractures in older women. Vitamin B12-deficiency anaemia is also not uncommon.

Long-term use of PPIs has also been implicated in the development of iron and magnesium deficiency.

Proton pump inhibitors can also cause Interstitial nephritis (Drug-induced Nephropathy).

Rebound gastric acid hypersecretion occurs even after relatively, short-term usage (2 months) and may last for up to 2 months after, the PPI has been discontinued.

Gradual tapering of the PPI and switching to an H2 receptor antagonist (e.g. Ranitidine) may prevent this from occurring.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Tushar Kanti Biswas, Internal Medicine Specialist
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Can Omez Be Safely Taken For A Long Duration?

Hello, Long-term acid suppression, especially with PPIs (Proton Pump Inhibitors e.g. Omeprazole), has been associated with a higher incidence of community-acquired pneumonia as well as community and hospital-acquired Clostridium difficile–associated disease. Long-term use of PPIs is also associated with the development of hip fractures in older women. Vitamin B12-deficiency anaemia is also not uncommon. Long-term use of PPIs has also been implicated in the development of iron and magnesium deficiency. Proton pump inhibitors can also cause Interstitial nephritis (Drug-induced Nephropathy). Rebound gastric acid hypersecretion occurs even after relatively, short-term usage (2 months) and may last for up to 2 months after, the PPI has been discontinued. Gradual tapering of the PPI and switching to an H2 receptor antagonist (e.g. Ranitidine) may prevent this from occurring. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Tushar Kanti Biswas, Internal Medicine Specialist