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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Methotrexate cause tooth decay?

Can methotrexate cause tooth decay? I was on the medication for nearly two years and my teeth started to decay, my gums became swollen and were bleeding from time to time. However, since I have discontinued the medication there have been no instances of tooth decay and my gums no longer swell or bleed.

Thank you
Fri, 7 Aug 2015
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Dentist 's  Response

I have gone through your query and can understand your concerns....

As per your complain Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and rheumatoid arthritis.
Methotrexate has no direct effect on the teeth and gums but it is seen to cause mouth ulcers and dryness of mouth..
Dry mouth can lead to increase in the incidence of caries and gum diseases due to lack of flushing action by the saliva which flushes off debris from the teeth and gums which can cause infection in the absence of saliva..
As you have stopped the intake of Methotrexate there must be relieve in the dryness of mouth and thus the dental decay has also reduced or ceased..
You need not to worry as you still have to continue the intake of this medicine you can still reduce the incidences of infection by maintaining proper oral hygiene and taking drugs that stimulate saliva secretion like Pilocarpine and drinking plenty of water..
Along with it professional guidance by a dentist by getting regular dental checkups can help..

Hope this information helps..

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Thanks and regards..
Dr.Honey Nandwani Arora..
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