My 18 year old daughter is has been taking 10 mg of methotrexate weekly and 50 mg Enbrel, injectable, weekly. She has been on these meds for approx. 1-1/2 years. Can these medications cause bladder problems? She feels the need to constantly urinate and gets up several times at night to do so. She will use the bathroom and then feel the need to urinate within five minutes again during the day.