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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can C-diff Cause Dysplasia Recurrence?

Hi, I was diagnosed with C-diff about 3 weeks ago I am on my second round of antibiotics as the first round did not work... I also have had severe dysplasia that has required a leep and laser about 3 years ago. Can the c diff affect the dysplasia in any way to make it reoccur?
Tue, 19 Apr 2016
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General & Family Physician,  's  Response
Hi & Welcome to HCM.
Recurrent dysplasia is not associated with Clostridium difficile infection.
Clostridium difficile infection occurs after the normal gut flora has been altered by antibiotic therapy. It is one of the most common caused of antibiotic associated opportunistic infection resulting in severe bloody diarrhea, abdominal cramps, dehydration, etc. The recurrent infection which sometimes occurs in about 30-40% of cases following a course of antibiotics (such as Metronidazole and Vancomycin) does not cause dysplasia of the colon.
Recurrent colonic dysplasia could be a pre-cancerous condition which needs to be investigated by doing a biopsy.
Hope I could answer your query.
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Can C-diff Cause Dysplasia Recurrence?

Hi & Welcome to HCM. Recurrent dysplasia is not associated with Clostridium difficile infection. Clostridium difficile infection occurs after the normal gut flora has been altered by antibiotic therapy. It is one of the most common caused of antibiotic associated opportunistic infection resulting in severe bloody diarrhea, abdominal cramps, dehydration, etc. The recurrent infection which sometimes occurs in about 30-40% of cases following a course of antibiotics (such as Metronidazole and Vancomycin) does not cause dysplasia of the colon. Recurrent colonic dysplasia could be a pre-cancerous condition which needs to be investigated by doing a biopsy. Hope I could answer your query.