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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Are there any side effects of taking Carbamazepine and Arip MT during conception?

Dear Sir,

My wife has facing psychiatric problem from last 1year. Now she is quit better than before.

She is taking the tablet from Carbamazepine,Lithum & Arip MT -15.

Sir what is the side effect of these tablet can we facing any problem if she want to

be mother.

Please help me to answer this question.


With Regards

Sabyasachi Chatterjee



Thu, 23 Feb 2017
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OBGYN 's  Response
Hi ,
How are you doing ?
These medicines are to control the psychiatric problems.
All three drugs do cause defects in the newly formed baby, these defects are usually multiple & not correctable.
Carbamazepine can cause - Spina bifida, craniofacial defects, cardiovascular malformations, hypospadias, and anomalies involving various body systems.
But instead of this combination, if used alone, this can be safer
Lithium can cause - heart defect, sudden death of baby etc better avoided in pregnancy
Arip MT is contraindicated in pregnancy, only animal studies are available.
So if I may advise, kindly consult your Neurologist & change over to less toxic drugs , reduce the dosage gradually under supervision & if possible switch to single drug. Once all stabilized pregnancy will be okay.
This can avoid all the unnecessary anxiety with the medicines with known teratogenicity.
Hope I have clarified your query, do write back if any more queries
All the best
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