Hello, my liver enzyme levels have been in the 400s. I am 44 years old and I do not drink alcohol and I have had my blood tested to check for all types of Hepatitis which all came back negative. I also had an ultrasound of my liver and gallbladder which also came back normal. I also have not taken any medications that would raise my liver enzymes. the only thing I do use if Afrin nasal spray quite often for sinus problems. My doctor wants me to have a liver biopsy and I wonder if its really necessary or not. Are there any other alternatives to the liver Biopsy. I am 5'-9" and I weigh about 230.