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64 yr old, diagnosed mylofibrosis, decreasing bone marrow size, needs blood each month. Any cure ?

my father age is 64 name AAAAA before we check up they diagnosis as mylofibrosis at that time born marrow size is increace but after starting medicine it is decreace but 300 gm bottle blood we use in one month on his body , we use blood on his body each month so plz tell me any solution for this diease and any tretment available and also explain me bone marro transplant also
Asked On : Tue, 27 Nov 2012
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Pathologist and Microbiologist 's  Response
Hello and welcome to HCM
Myelofibrosis is a chronic myeloproliferative disorder. It is characterised by replacement of bone marrow by fibrosis. Normally, bone marrow contains hematopoietic cells which produce red blood cells (RBC), white blood cells (WBC) and platelets.
In myelofibrosis is a condition where these hematopoetic cells are replaced leading to reduced production of cells of all these three lineage.
Decrease in blood components requires regular blood transfusion.
Bone marrow transplantation is the permanent cure but the success rate of bone marrow transplant varies from centre to centre and from patient to patient.
Bone marrow transplantation requires a donor with HLA matching.
HLA matching is done among blood relations. Siblings have the highest chance of matching.
This is a sophisticated procedure done at tertiary health care level.
Some of the centres performing bone marrow transplant are: Christian Medical College Vellore & Ludhiana, Tata Medical centre Kolkatta, Apollo hospitals, AIIMS etc.
You can visit an oncology centre nearest to your place.

Thank you and take care
Dr Shailja P Wahal
Answered: Wed, 28 Nov 2012
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