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Could High PSA Level Be Due To Acidosis, The Inflammation In His Digestive System Or A Cancer?

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Posted on Thu, 24 Sep 2020
Question: hello, my husband needs help. he is a 68 year of XXXXXXX XXXXXXX male with a high psa level -8.65 - it has gone from 5.3 to today - 8.65 in 1 year. now let me give you the facts. we believe at his age, he might have an enlarged prostate, but none of the 2 doctors he has seen in the past 1 year has told him so.
we also believe that because of his acidosis, the inflammation in his digestive system may have also contributed to this high number. he take a lot of herbal supplements, about 15 per day and this too may have attributed to his high number.
because of the acidosis, he has developed gluten problems and just haven't eaten like he used to, so he lost 25 pounds in 1 year.
he was tested this past august and his prostate number was 6. they did a dre test and found a nodule which he had a transrectal ultrasound and sonogram of his prostate, his liver and kidneys - all were ok - they just put on the report that maybe he should have more tests run.
his current doctor only wants to discuss biopsies and won't listen to the reasons we've listed below.
he is healthy and have no symptoms. i just need another opinion because i don't want my husband being a part of the statistic where 750,000 men have un-needed biopsies.
we will consider an mri, but want we want to know is this. doesn't it make a difference if his free psa percentage score is 32% as we read if it were over 25% chances are he doesn't have cancer and doesn't it seem plausible with the transrectal ultrasound and sonogram that he doesn't have cancer? please advise. thank you so very much for being out there for us. i don't know if i mentioned it or not, but his other doctor put him on 1000 mg. of antibiotic for what she thought might be a prostatitis infection, but this urologist told him to stop taking it - didn't check my husband out nor refer to any of the blood work - although he is not experiencing any symptoms of a prostatitis.
doctor
Answered by Dr. Deepak Sundriyal (49 minutes later)
Brief Answer:
Hello. A biopsy is needed

Detailed Answer:
Hello dear. I understand your concern. So the reasons which you mentioned like herbal or acidosis does not lead to high psa. Since clinical examination is also suggesting a nodule and psa is in grey zone, a biopsy is justifies. You can wait for a couple of month, if not immediately, if it shows a rising psa then a biopsy can be done.
Thanks and regards
Feel free to ask further
Above answer was peer-reviewed by : Dr. Yogesh D
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Follow up: Dr. Deepak Sundriyal (25 minutes later)
thank you for such a prompt reply. what do you think about inflammation in the system causing a high psa? how about constipation or just an enlarged prostate? these are things i've researched as well as possible prostate cancer.

can you tell me what your thoughts of a free psa score being 32% because as you well know anything below 25% would indicate possible cancer.

i just feel you just can't go on the high psa number alone as it takes several factors to be cancer.

i would also like to know how you feel about an mri. did you know that 750,000 men in 2017 had a biopsy and none of them had cancer. we just don't want to be a statistic. thank you for your time. XXXXXXX
doctor
Answered by Dr. Deepak Sundriyal (41 minutes later)
Brief Answer:
Hello. Body inflammation is not related

Detailed Answer:
Hello dear. So inflammatin the body wont give rise to high psa except inflammation or infection of prostate itself which will manifest into pain and burning sensation during micturition. I agree that many of these biopsies turned out to be negative but in the background of hard nodule felt in prostate, biopsy is justified. We generally donot give much attention to free psa.
You can wait for 3 months and see if psa is rising. If it is, then go for biopsy otherwise defer.
Thanks and regards
Feel free to ask further
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Deepak Sundriyal (58 minutes later)
thank you sir. his other doctor put him on 1000 mg. of cipro for 30 days. would you agree that all of this increase in psa might be attributed to prostatitis? if not, why would she have put him on this if she hadn't seen something on the report?

of course, the urologist we seen today just shrugged it off when i presented the question to him.

my husband has been on cipro for a week now and i understand in doing my own research that sometimes antibiotics will have an affect on high psa levels.

he has been off cipro now for a day and he feels that he has less stream when he urinates which when he was on cipro, he had full stream.

of course we want what is best for my husband, i just want him having to go through unnecessary biopsies for obvious possible situations, like prostatitis.

how do you feel about the mri testing? hard nodules i understand in my research can be caused by inflammation in the body.

i am just looking for an unbiased opinion of other things it could be because he took a transrectal ultrasound and a cat scan 7 months ago when he had this nodule and nothing was conclusive then. i so appreciate you. XXXXXXX
doctor
Answered by Dr. Deepak Sundriyal (5 hours later)
Brief Answer:
Hello. prolonged antibiotic is not justified

Detailed Answer:
Hello.

So prolonged course of antibiotics is not justified if there is no evidence of infection in urine or on imaging.
MRI can help diagnosing a tumor but a biopsy is must to diagnose cancer with certainty.
In my opinion, wait for 3 months and then repeat PSA. If high, then go for biopsy.

Thanks and regards
Feel free to ask further
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Deepak Sundriyal (2 hours later)
thank you!! this is what my research has found and i am confused as to why men have to go through painful biopsies if indeed mri's can detect prostate cancer. we will have the mri done today to see if there are any tumors and from what i am reading, the mri can detect cancer as well. in your opinion, why get a biopsy also?

Magnetic resonance imaging (MRI) Like CT scans, MRI scans show detailed images of soft tissues in the body. ... MRI scans can give a very clear picture of the prostate and show if the cancer has spread outside the prostate into the seminal vesicles or other nearby structures.May 15, 2017
doctor
Answered by Dr. Deepak Sundriyal (39 minutes later)
Brief Answer:
Hello. Biopsy confirms the disease

Detailed Answer:
Hello. A histological proof is necessary prior starting any treatment and hence biopsy is must. Moreover, sometimes it helps us to change the chemotherapy also.
Thanks and regards
Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Deepak Sundriyal (19 minutes later)
thank you for your time sir; we will wait and see what the mri test reveals. he has
thisis the findings from the ultrasound of the prostate this past october:

the prostate measures 6.3x6.4x5.0 for a calculated volume of 100ml. predicted psa per volume is 11.9. central gland measures 3.7x5.6cm. there are cystic changes within the central gland as well as coarse calcification in keeping with benign prostatic hypertrophy.

he has multiple hypoechoic nodules within the peripheral zone. findings of benign prostatic hypertrophy. urinary bladder diverticulum suggests chronic outlet obstruction.
doctor
Answered by Dr. Deepak Sundriyal (1 hour later)
Brief Answer:
Hello. Yes wait and watch policy is ok

Detailed Answer:
Hello dear. Yes you can go for mri and wait n watch policy.
Thanks and regards

Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Deepak Sundriyal (8 minutes later)
God bless you Dr. XXXXXXX and i will tell everyone about this site.
thank you!
doctor
Answered by Dr. Deepak Sundriyal (0 minute later)
Brief Answer:
You are welcome

Detailed Answer:
Welcome..
Thanks and regards
Note: Consult a Urologist online for consultation about prostate and bladder problems, sexual dysfunction, kidney stones, prostate enlargement, urinary incontinence, impotence and erectile dysfunction - Click here.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Deepak Sundriyal

Oncologist

Practicing since :2005

Answered : 1617 Questions

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Could High PSA Level Be Due To Acidosis, The Inflammation In His Digestive System Or A Cancer?

Brief Answer: Hello. A biopsy is needed Detailed Answer: Hello dear. I understand your concern. So the reasons which you mentioned like herbal or acidosis does not lead to high psa. Since clinical examination is also suggesting a nodule and psa is in grey zone, a biopsy is justifies. You can wait for a couple of month, if not immediately, if it shows a rising psa then a biopsy can be done. Thanks and regards Feel free to ask further