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can I take sildenafil with omeprazole

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Posted on Thu, 14 Feb 2019
Question: can I take sildenafil with omeprazole
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Answered by Dr. Vaishalee Punj (1 hour later)
Brief Answer:
Reports of omeprazole to cause erectile dysfunction

Detailed Answer:
Hello and welcome to Ask A Doctor service.

I have reviewed your query and here is my advice.

There are some reports that Omeprazole can cause erectile dysfunction. Also omeprazole inhibits the cytochrome enzymes and sidenafil is metabolized by some of them. So theoretically there maybe accumulation of sildenafil.

But I could not find clinically relevant drug interactions between the two medicines and these can be combined. To be safe, take lower dose of sildenafil.

Dr Vaishalee
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Dr. Vaishalee Punj

General & Family Physician

Practicing since :2003

Answered : 2601 Questions

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can I take sildenafil with omeprazole

Brief Answer: Reports of omeprazole to cause erectile dysfunction Detailed Answer: Hello and welcome to Ask A Doctor service. I have reviewed your query and here is my advice. There are some reports that Omeprazole can cause erectile dysfunction. Also omeprazole inhibits the cytochrome enzymes and sidenafil is metabolized by some of them. So theoretically there maybe accumulation of sildenafil. But I could not find clinically relevant drug interactions between the two medicines and these can be combined. To be safe, take lower dose of sildenafil. Dr Vaishalee