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Is There A Reaction Between Paxil And Zaralto?

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Posted on Tue, 22 Sep 2020
Question: Yes is there a reaction between paxil and zaralto
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Answered by Dr. Vaishalee Punj (1 hour later)
Brief Answer:
What type of reaction?

Detailed Answer:
Hi
Thanks for your query.

Do you want to know about any possible reaction between Paxil and Zaralto?
Are you experiencing any side effects?

There is one known interaction between the two: Zaralto is metabolised by CYP3A4 and Paxil inhibits this enzyme. There are chances of increased side effects of Zaralto when given with Paxil.

As per a reference from a research article: Therefore, since rivaroxaban is metabolized by CYP3A4, antidepressants that are inhibitors of this isoenzyme, such as fluoxetine, sertraline, paroxetine and fluvoxamine must be avoided. Based on drug interactions in cytochrome p450, the use of escitalopram, citalopram, venlafaxine, mirtazapine or milnacipran would be safer in such patients since these drugs have a minimum CYP 450 inhibition potential.

Hope it helps. Let me know if I can assist you further.
Dr Vaishalee
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Vaishalee Punj

General & Family Physician

Practicing since :2003

Answered : 3258 Questions

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Is There A Reaction Between Paxil And Zaralto?

Brief Answer: What type of reaction? Detailed Answer: Hi Thanks for your query. Do you want to know about any possible reaction between Paxil and Zaralto? Are you experiencing any side effects? There is one known interaction between the two: Zaralto is metabolised by CYP3A4 and Paxil inhibits this enzyme. There are chances of increased side effects of Zaralto when given with Paxil. As per a reference from a research article: Therefore, since rivaroxaban is metabolized by CYP3A4, antidepressants that are inhibitors of this isoenzyme, such as fluoxetine, sertraline, paroxetine and fluvoxamine must be avoided. Based on drug interactions in cytochrome p450, the use of escitalopram, citalopram, venlafaxine, mirtazapine or milnacipran would be safer in such patients since these drugs have a minimum CYP 450 inhibition potential. Hope it helps. Let me know if I can assist you further. Dr Vaishalee