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Dr. Andrew Rynne

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Would Benadryl cause Peyronie's disease after long term use?

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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3478 Questions

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Posted on Tue, 24 Apr 2018 in Medicines and Side Effects
Question: I have been taking Benadryl every night for years and just read where it could be a cause for my Pyronnies problems. What’s your opinion .
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Answered by Dr. Panagiotis Zografakis 42 minutes later
Brief Answer:
no...

Detailed Answer:
Hello,

diphenhydramine (benadryl) does not seem to be connected in any way with Peyronie's disease. I've never ever heard or read anything about it. Peyronie's disease is a little enigmatic in etiology. It occurs more commonly in people who:
-smoke
-have diabetes
-are older
-have lipid disorders
-have vitamin E deficiency
-have Dupuytren's contracture

Injuries may also cause this disease.

Benadryl may make erectile dysfunction worse in some patients.

I hope you find my comments helpful!
Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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