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Would Benadryl cause Peyronie's disease after long term use?

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Internal Medicine Specialist
Practicing since : 1999
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I have been taking Benadryl every night for years and just read where it could be a cause for my Pyronnies problems. What’s your opinion .
Tue, 24 Apr 2018 in Medicines and Side Effects
Answered by Dr. Panagiotis Zografakis 42 minutes later
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Detailed Answer:

diphenhydramine (benadryl) does not seem to be connected in any way with Peyronie's disease. I've never ever heard or read anything about it. Peyronie's disease is a little enigmatic in etiology. It occurs more commonly in people who:
-have diabetes
-are older
-have lipid disorders
-have vitamin E deficiency
-have Dupuytren's contracture

Injuries may also cause this disease.

Benadryl may make erectile dysfunction worse in some patients.

I hope you find my comments helpful!
Kind Regards!
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