mechanism of action of drug detailed below
The medications in schizophrenia
act by blocking the D2 receptors in the frontal area of brain and the disease is caused by excessive Dopamine
(a chemical called Neurotransmitter
) in the spaces between nerve
cells. It results in excessive stimulation of certain neuronal pathways, leading to symptoms of schizophrenia. Medicines help to bring back the level of stimulation to appropriate level. if the neuronal pathways are continuously or repeatedly stimulated ( by not taking medicines, discontinuing or reappearance of symptoms due to stress
), there is death of cells hence the when you give me dines later on, it may find lesser number of cells to reduce stimulation by dopamine . This is seen clinically as reduced response to medicines.
I hope I have been able to explain why someone responsive to medicines initially, can become resistant later on.
Dr Saatiish Jhuntrraa